NY Valves 2026 – Dr Rajiveta Guddeti (The Christ Hospital, Cincinnati, US) discusses one-year outcomes from a real-world registry evaluating the Navitor transcatheter valve in patients with small aortic annuli, a high-risk subgroup often associated with elevated gradients and patient–prosthesis mismatch (PPM).

In this interview, Dr Guddeti highlights favourable haemodynamics with single-digit gradients (~8.7 mmHg), low severe PPM (3.6%) and minimal PVL (1.8%), alongside key procedural considerations including routine pre-dilatation, 10–15% sizing and precise implantation depth. She also outlines how Navitor’s intra-annular, self-expanding design and sealing cuff may underpin these outcomes, while noting important limitations of the single-arm registry data.

Interview Questions:

1. What were the key clinical and haemodynamic signals you observed with Navitor in small aortic annuli in this real-world registry?
2. How do you think Navitor’s design features explain the outcomes seen in this population?
3. Which small-annulus anatomies have become your ‘sweet spot’ for Navitor?
4. What technical refinements have you made to optimise gradients and minimise PPM and PVL?
5. What limitations should clinicians consider when interpreting these data?

Recorded remotely from Cincinnati, 2026.