TCT 2025 — Dr Nadira Hamid (Minneapolis Heart Institute, US) and Dr Rahul P Sharma (Stanford University, US) review the late-breaking trial data shaping the future of structural heart disease. 
The discussion highlights real-world results from TRISCEND and TRILUMINATE in tricuspid disease, 7-year PARTNER 3 durability outcomes in TAVR, national prevalence insights from the PREVUE-VALVE study, and new frontiers in mitral intervention with SUMMIT MAC. Together, they examine what the evidence means for safety, durability, patient selection, and clinical adoption.
 

01:35 – Tricuspid Therapies
Late-breaking data from TRILUMINATE (TriClip) and TRISCEND (Evoque): real-world outcomes, bleeding reduction, pacemaker trends, and patient selection.

07:01 – Aortic Valve Durability
PARTNER 7-year outcomes: TAVR vs. SAVR, valve performance over time, implications for younger/lower-risk patients, and evolving device technology.

13:24 – Valvular Disease Prevalence
Insights from the PREVUE-VALVE: first nationwide prevalence data, under-treatment of severe disease, and role of AI in early detection.

16:48 – Mitral Valve Advances
Landmark trials: SUMMIT Trial (MAC population) and first-in-human Sapien M3 transseptal TMVR. Key outcomes, screen failure rates, and implications for clinical adoption.

24:50 – Future of Structural Heart Interventions
Patient-first approach, expanding treatment options, and importance of durability and early diagnosis.

For more content from TCT 2025 head to the Late-breaking Science Video Collection.

Editor: Mirjam Boros
Videographer: Tom Green and Dan Brent

Support: This is an independent video produced by Radcliffe Cardiology.